| 货号 | 产品名称 | 规格 | 库存 | 价格 | 数量 | 购买 |
|---|---|---|---|---|---|---|
| KR0258 | IL-33, Mouse, Recombinant | 10ug |
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| 分子量 | 17.6 kDa |
|---|---|
| 表观分子量 | 18 kDa |
| 片段与标签 | Ser109-Ile266 |
| 生物活性 | Measured by its ability to bind Mouse IL-1 R4 in functional ELISA. Immobilized recombinant Mouse IL33 at 5 μg/ mL can bind Mouse IL1RL1with a linear range of 0.625-5ug/ ml. |
| 物种 | Mouse |
| 表达宿主 | E.coli |
产品特性
| 纯度 | ＞95% as determined by reducing SDS-PAGE. |
|---|---|
| 内毒素 | ＜1.0 EU per μg as determined by LAL test. |
| 保存 | Lyophilized Protein should be stored at ＜ -20℃, though stable at room temperature for 3 weeks.Reconstituted Protein solution can be stored at 4-7℃ for 2-7 days.Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months |
产品介绍
Mouse Interleukin 33 (IL-33) is a 30 kDa proinflammatory Cytokine which may also regulates gene transcription in producer cells. IL-33 is constitutively expressed in smooth muscle and airway epithelia. IL-33 was identified based on sequence and structural homology with IL-1 family Cytokines. It is up-regulated in arterial smooth muscle, dermal fibroblasts, and keratinocytes following IL-1 alpha or IL-1 beta stimulation. IL-33 is structurally related to IL-1, which induces helper T cells to produce type 2 Cytokines and acts through the Receptor IL1RL-1. BindingIL-33 to this Receptor activates NF-kappa-B and MAP kinases and induces in vitro Th2 cells to produce Cytokines. In vivo, IL-33 induces the expression of IL-4, IL-5, IL-13 and also leads to severe pathological changes in mucosal organs.
