| 货号 | 产品名称 | 规格 | 库存 | 价格 | 数量 | 购买 |
|---|---|---|---|---|---|---|
| KR0191 | IL-31, Human, Recombinant | 10ug |
+
-
|
|
| 分子量 | 15.8 kDa |
|---|---|
| 表观分子量 | 15 kDa |
| 片段与标签 | Ser24-Thr164 |
| 生物活性 | Measured by inducing STAT3 activation in U87 MG human glioblastoma/ astrocytoma cells.The ED50 for this effect is less than 45 ng/ mL. |
| 物种 | Human |
| 表达宿主 | E.coli |
产品特性
| 纯度 | ＞95% as determined by reducing SDS-PAGE. |
|---|---|
| 内毒素 | ＜1.0 EU per µg as determined by LAL test. |
| 保存 | Lyophilized Protein should be stored at ＜ -20℃, though stable at room temperature for 3 weeks.＜br/ >Reconstituted Protein solution can be stored at 4-7℃ for 2-7 days.＜br/ >Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months |
产品介绍
Human Interleukin 31 (IL-31) is a Cytokine containing a four-helix bundle structure. It shares several structural and functional characteristics with IL-6, Oncostatin M, LIF, and Cardiotrophin-1. Human IL-31 cDNA encodes a 164 amino acid precursor that contains a 23 amino acid signal peptide and a 141 amino acid mature Protein. Human and mouse IL-31 share 24% sequence identity in the mature region. IL-31 is mainly associated with activated T cells and is preferentially expressed by type 2 helper T cells (Th2). IL-31 signals via a heterodimeric Receptor complex composed of a gp130 related molecule termed IL-31RA (also GPL and GLMR) and an Oncostatin M Receptor (OSM Rβ). The IL-31 Receptor is constitutively expressed by keratinocytes and upregulated by IFNγ on monocytes. GPL/ OSMR signaling is a strong activator of STAT3 and STAT5, and can also activate STAT1, Jak1, and Jak2 signaling pathways. IL-31 regulated immune responses have been implicated in skin physiology and inflammatory skin diseases. Studies have shown that IL31 induces severe pruritis (itching) and dermatitis in transgenic mice.
