| 货号 | 产品名称 | 规格 | 库存 | 价格 | 数量 | 购买 |
|---|---|---|---|---|---|---|
| KR0180 | IL-18/ IL-1F4, Human, Recombinant | 10ug |
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| 分子量 | 18.2 kDa |
|---|---|
| 表观分子量 | 17 kDa |
| 片段与标签 | Tyr37-Asp193 |
| 生物活性 | Measured by its ability to induce NFKB reporter gene expression in HEK 293 cell line.The ED50 for this effect is less than 25ng/ mL. |
| 物种 | Human |
| 表达宿主 | E.coli |
产品特性
| 纯度 | ＞95% as determined by reducing SDS-PAGE. |
|---|---|
| 内毒素 | ＜1.0 EU per µg as determined by LAL test. |
| 保存 | Lyophilized Protein should be stored at ＜ -20℃, though stable at room temperature for 3 weeks.Reconstituted Protein solution can be stored at 4-7℃ for 2-7 days.Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months |
产品介绍
Interleukin-18 is a secreted Protein and it belongs to the IL-1 family. IL-18 is a proinflammatory Cytokine and produced by macrophages and other cells. This Cytokine can induce the IFN-gamma production of T cells. The combination of this Cytokine and IL12 has been shown to inhibit IL-4 dependent IgE and IgG1 production, and enhance IgG2a production of B cells. IL-18 binding Protein (IL18BP) can specifically interact with this Cytokine, and thus negatively regulate its biological activity. After stimulation with IL-18, natural killer (NK) cells and certain T cells release another important Cytokine called interferon-γ (IFN-γ) or type II interferon that plays an important role in activating the macrophages or other cells.
