| 货号 | 产品名称 | 规格 | 库存 | 价格 | 数量 | 购买 |
|---|---|---|---|---|---|---|
| KR0183 | IL-21R/ CD360, Human, Recombinant | 10ug |
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| 分子量 | 26.0 kDa |
|---|---|
| 表观分子量 | 46 kDa |
| 片段与标签 | Cys20-Pro236 C-6His |
| 生物活性 | Measured by its ability to bind human IL-21 in a functional ELISA. Measured by its ability to inhibit IL21-induced Interferon gamma secretion by human natural killer lymphoma NK-92 cells. The ED50 for this effect is typically 1-5 ng/ ml in the presence of 10 ng/ ml of recombinant human IL23. Measured by its ability to inhibit IL21-induced Interferon gamma secretion by human natural killer lymphoma NK-92 cells. The ED50 for this effect is typically 50-200 pg/ mL in the presence of 1 ng/ ml of recombinant human IL21. |
| 物种 | Human |
| 表达宿主 | Human Cells |
产品特性
| 纯度 | ＞95% as determined by reducing SDS-PAGE. |
|---|---|
| 内毒素 | ＜1.0 EU per µg as determined by LAL test. |
| 保存 | Lyophilized Protein should be stored at ＜ -20℃, though stable at room temperature for 3 weeks.Reconstituted Protein solution can be stored at 4-7℃ for 2-7 days.Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months |
产品介绍
Interleukin-21 Receptor is also known as IL-21 Receptor, IL-21R, CD360. In humans, it is encoded by the IL21R gene. It belongs to the type I Cytokine Receptor family. Type 4 subfamily contains 2 fibronectin type-III domains. Interleukin-21 Receptor is selectively expressed in lymphoid tissues and highly expressed in thymus and spleen. IL-21 is produced by CD4+ T cells in response to antigenic stimulation. Its action enhances antigen-specific responses of immune cells. The biological effects of IL-21 include induction of differentiation of T-cells-stimulated B-cells into plasma cells and memory B-cells. It also promotes the anti-tumor activity of CD8+ T-cells and NK cells.
