| 货号 | 产品名称 | 规格 | 库存 | 价格 | 数量 | 购买 |
|---|---|---|---|---|---|---|
| KR0161 | IFN-λ2/ IL-28A (C-6His), Human, Recombinant | 10ug |
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| 分子量 | 20.6 kDa |
|---|---|
| 表观分子量 | 20 kDa |
| 片段与标签 | Val26-Val200 C-6His |
| 生物活性 | Testing in progress |
| 物种 | Human |
| 表达宿主 | Human Cells |
产品特性
| 纯度 | ＞95% as determined by reducing SDS-PAGE. |
|---|---|
| 内毒素 | ＜1.0 EU per µg as determined by LAL test. |
| 保存 | Lyophilized Protein should be stored at ＜ -20℃, though stable at room temperature for 3 weeks.Reconstituted Protein solution can be stored at 4-7℃ for 2-7 days.Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months |
产品介绍
IL-28A (Interferon-λ2? IFN-λ2), IL-28B/ IFN-λ3, and IL-29/ IFN-λ1 are type III interferons which are distantly related to IL-10 family and type I IFN family Cytokines. Mature human IL-28A is an approximately 22-25 kDa Protein that shares 66% amino acid (aa) sequence identity with mouse and rat IL-28A and shows cross-species activity. It shares 96% and 70% aa sequence identity with human IL-28B and IL-29, respectively. IL-28A promotes the Th1 polarization of dendritic cells in the airway and inhibits Th2 and Th17 mediated inflammation. IL-28A additionally exhibits anti-tumor activity, in part by enhancing IL-12 dependent anti-tumor CTL responses in vivo. In contrast, it is up-regulated in invasive bladder cancer where it promotes tumor cell migration.
