| 货号 | 产品名称 | 规格 | 库存 | 价格 | 数量 | 购买 |
|---|---|---|---|---|---|---|
| KR0233 | Fractalkine/ CX3CL1 (C-6His), Mouse, Recombinant | 10ug |
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| 分子量 | 34.3 kDa |
|---|---|
| 表观分子量 | 58-60 kDa |
| 片段与标签 | Gln25-Arg337 C-6His |
| 生物活性 | Testing in progress |
| 物种 | Mouse |
| 表达宿主 | Human Cells |
产品特性
| 纯度 | ＞95% as determined by reducing SDS-PAGE. |
|---|---|
| 内毒素 | ＜1.0 EU per μg as determined by LAL test. |
| 保存 | Lyophilized Protein should be stored at ＜ -20℃, though stable at room temperature for 3 weeks.Reconstituted Protein solution can be stored at 4-7℃ for 2-7 days.Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months |
产品介绍
Fractalkine (CX3CL1) is a single-pass type I membrane Protein and belongs to the intercrine delta family. It consists of an extracellular NH2-terminal domain, a mucin-like stalk, a transmembrane α helix, and a short cytoplasmic tail. CX3CL1 exists in two forms: as a membrane-anchored or as a shed 80-95K glyco Protein. Soluble CX3CL1 is generated by limited proteolysis on the cell surface, and a disintegrin and metallopeptidase 10 (ADAM10) and ADAM17/ tumor necrosis factor-α-converting enzyme (ADAM17/ TACE) participate in this shedding. It has been suggested that ADAM10 acts in the constitutive shedding, and ADAM17 acts in response to cell activation. The Protein may play a role in regulating leukocyte adhesion and migration processes at the endothelium.
