| 货号 | 产品名称 | 规格 | 库存 | 价格 | 数量 | 购买 |
|---|---|---|---|---|---|---|
| KR0155 | IL-23R (C-Fc), Human, Recombinant | 10ug |
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| 分子量 | 65.0 kDa |
|---|---|
| 表观分子量 | 90-120 kDa |
| 片段与标签 | Gly24-Asp353 C-Fc |
| 生物活性 | Measured by its ability to binding recombinant human IL-23A&IL12B used funtional ELISA. The ED50 for this effect is less than 5 ug/ ml. |
| 物种 | Human |
| 表达宿主 | Human Cells |
产品特性
| 纯度 | ＞90% as determined by reducing SDS-PAGE. |
|---|---|
| 内毒素 | ＜1.0 EU per µg as determined by LAL test. |
| 保存 | Lyophilized Protein should be stored at < -20℃, though stable at room temperature for 3 weeks |
产品介绍
Interleukin 23 Receptor (IL23R) is a type I Cytokine Receptor for IL23. IL23 Receptor complex is comprised of two subunits, the IL12Rβ1 subunit, which is shared with several Cytokines, and a subunit that is unique to IL-23. IL23, after binding to IL23R, activates memory T cells and mediates pro-inflammatory activities in part by the production of IL17 through activation of TH17 lymphocytes. IL23R is expressed on T cells, NK cells, dendritic cells, and macrophages. In fact, polymorphisms of the IL23R gene were reported to be associated with susceptibility to inflammatory diseases and autoimmune diseases such as psoriasis, multiple sclerosis, Graves' s ophtalmopathy and inflammatory bowel diseases. The IL23R is known to be critically involved in the carcinogenesis of different malignant tumor.
