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GITR/ TNFRSF18/ CD357 (C-6His), Human, Recombinant

  • 货号:KR0143
货号 产品名称 规格 库存 价格 数量 购买
KR0143 GITR/ TNFRSF18/ CD357 (C-6His), Human, Recombinant 10ug

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分子量 15.3 kDa
表观分子量 16 &18 kDa
片段与标签 Glu74-Ser199 C-6His
生物活性 Testing in progress
物种 Human
表达宿主 Human Cells

 

产品特性

 

纯度 >90% as determined by reducing SDS-PAGE.
内毒素 <1.0 EU per µg as determined by LAL test.
保存 Lyophilized Protein should be stored at < -20℃, though stable at room temperature for 3 weeks.Reconstituted Protein solution can be stored at 4-7℃ for 2-7 days.Aliquots of reconstituted samples are stable at < -20℃ for 3 months

 

产品介绍

TNFSF18 is a single-pass type II membrane Protein. It is expressed at high levels in the small intestine, ovary, testis, kidney and endothelial cells. TNFSF18 Cytokine binds to TNFRSF18/ AITR/ GITR. It regulates T-cell responses, and functions as costimulator and lower the threshold for T-cell activation and T-cell proliferation. It is Important for interactions between activated T-lymphocytes and endothelial cells and Promotes leukocyte adhesion to endothelial cells. TNFSF18 mediates activation of NF-kappa-B. As Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1. It also regulates migration of monocytes from the splenic reservoir to sites of inflammation.

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