| 货号 | 产品名称 | 规格 | 库存 | 价格 | 数量 | 购买 |
|---|---|---|---|---|---|---|
| KR0060 | RANK L/ TRANCE/ TNFSF11 (N-6His), Human, Recombinant | 10ug |
+
-
|
|
| 分子量 | 22.4 kDa |
|---|---|
| 表观分子量 | 20 kDa |
| 片段与标签 | Ile140-Asp317 N-6His |
| 生物活性 | Measured by its ability to binding SF11A used funtional ELISAThe ED50 for this effect is less than 10 ug/ ml. |
| 物种 | Human |
| 表达宿主 | E.coli |
产品特性
| 纯度 | ＞90% as determined by reducing SDS-PAGE. |
|---|---|
| 内毒素 | ＜1.0 EU per µg as determined by LAL test. |
| 保存 | Lyophilized Protein should be stored at < -20℃, though stable at room temperature for 3 weeks |
产品介绍
CD254, also known as RANKL, TNFSF11, TRANCE, OPGL and ODF, is a type II membrane Protein of the tumor necrosis factor (TNF) superfamily, and affects the immune system and control bone regeneration and remodeling. RANKL is the Ligand of nuclear factor (NF)-κB (RANK). When RANKL binds to RANK, it will undergo trimerization and then bind to an adaptor molecule TNF Receptor-associated factor 6 (TRAF6). This results in the activation of several downstream signaling cascades, including the NFκB, mitogen-activated Protein kinases (MAPK), activating Protein 1 (AP-1), and nuclear factor of activated T cells (NFATc1), resulting in the formation of multinucleated bone-resorbing osteoclasts. RANKL is widely expressed in skeletal muscle, thymus, liver, colon, small intestine, adrenal gland, osteoblast, mammary gland epithelial cells, prostate and pancreas.
