| 货号 | 产品名称 | 规格 | 库存 | 价格 | 数量 | 购买 |
|---|---|---|---|---|---|---|
| KR0201 | IL-4Rα/ CD124 (C-Fc), Human, Recombinant | 10ug |
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| 分子量 | 50.2 kDa |
|---|---|
| 表观分子量 | 60-70 kDa |
| 片段与标签 | Met26-Gln231 C-Fc |
| 生物活性 | Measured by its ability to inhibit IL-4-dependent proliferation of TF‑1 human erythroleukemic cells.The ED50 for this effect is less than 20 ng/ ml. |
| 物种 | Human |
| 表达宿主 | Human Cells |
产品特性
| 纯度 | ＞95% as determined by reducing SDS-PAGE. |
|---|---|
| 内毒素 | ＜1.0 EU per µg as determined by LAL test. |
| 保存 | Lyophilized Protein should be stored at ＜ -20℃, though stable at room temperature for 3 weeks.Reconstituted Protein solution can be stored at 4-7℃ for 2-7 days.Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months |
产品介绍
Interleukin 4 Receptor alpha (IL4-Ra) is a widely expressed 140 kDa transmembrane glyco Protein in the class I Cytokine Receptor family. Mature human IL4-Ra consists of a 207 amino acid (aa) extracellular domain (ECD) that contains a Cytokine binding region and one fibronectin type III domain, a 24 aa transmembrane segment, and a 569 aa cytoplasmic domain that contains one Box 1 Motif and one ITIM Motif. IL4-Ra plays an important role in Th2-biased immune responses, alternative macrophage activation, mucosal immunity, allergic inflammation, tumor progression, and atherogenesis. Soluble forms of IL4-Ra, generated by alternate splicing or proteolysis, retain Ligand binding properties and inhibit IL-4 bioactivity. IL4-Ra is a component of two distinct Receptor complexes and shows species selectivity between human and mouse. It can associate with the common gamma chain (γc) to form the IL-4 responsive type I Receptor in which γc increases the affinity for IL-4 and enables signaling. It can alternatively associate with IL13-Ra1 to form the type II Receptor which is responsive to both IL-4 and IL-13. The use of shared Receptor components contributes to the overlapping biological effects of IL-4 and IL-13 as well as other Cytokines that utilize γc.
