| 货号 | 产品名称 | 规格 | 库存 | 价格 | 数量 | 购买 |
|---|---|---|---|---|---|---|
| KR0167 | IL-1R-2/ CD121b, Human, Recombinant | 10ug |
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| 分子量 | 38.6 kDa |
|---|---|
| 表观分子量 | 50 kDa |
| 片段与标签 | Phe14-Glu343 C-6His |
| 生物活性 | Immobilized human IL1R2 at 10 μg/ ml (100 μl/ well) can bind biotinylated human IL1B-His, The EC50 of biotinylated human IL1B-His is 0.14-0.34 μg/ ml. |
| 物种 | Human |
| 表达宿主 | Human Cells |
产品特性
| 纯度 | ＞95% as determined by reducing SDS-PAGE. |
|---|---|
| 内毒素 | ＜1.0 EU per µg as determined by LAL test. |
| 保存 | Lyophilized Protein should be stored at ＜ -20℃, though stable at room temperature for 3 weeks.Reconstituted Protein solution can be stored at 4-7℃ for 2-7 days.Aliquots of reconstituted samples are stable at ＜ -20℃ for 3 months |
产品介绍
Interleukin-1 Receptor type 2 (IL1R2) belongs to the Interleukin-1 Receptor family. Two distinct types of IL1 Receptors which are able to bind IL1 specifically have been identified, designated as IL1RI (IL1RA) and IL1RII (IL1RB). IL1 Receptor type II is a 68 kDa transmembrane Protein found on B lymphocytes, neutrophils, monocytes, large granular leukocytes and endothelial cells. IL1R2 is non-signaling Receptor forIL1A, IL1B and IL1RN, reduces IL1B activities. IL1R2 serves as a decoy Receptor by competetive binding to IL1B and preventing its binding to IL1R1. IL1R2 modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/ soluble Receptors.
