| 货号 | 产品名称 | 规格 | 库存 | 价格 | 数量 | 购买 |
|---|---|---|---|---|---|---|
| KR0107 | IL-4Ra (C-6His), Cynomolgus, Recombinant | 10ug |
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| 分子量 | 24.6 kDa |
|---|---|
| 表观分子量 | 40 kDa |
| 片段与标签 | Met26-Arg232 |
| 物种 | Cynomolgus |
| 表达宿主 | Human Cells |
产品特性
| 纯度 | ＞95% as determined by reducing SDS-PAGE. |
|---|---|
| 内毒素 | ＜1.0 EU per µg as determined by LAL test. |
| 保存 | Lyophilized Protein should be stored at ＜ -20°C, though stable at room temperature for 3 weeks.Reconstituted Protein solution can be stored at 4-7°C for 2-7 days.Aliquots of reconstituted samples are stable at ＜ -20°C for 3 months. |
产品介绍
Interleukin-4 Receptor subunit alpha (IL-4RA), alos known as Soluble IL-4 Receptor subunit alpha, belongs tothe type I Cytokine Receptor family and type 4 subfamily. It expressed in both Th1 and Th2 cells. It functionsas Receptor for both Interleukin 4 and Interleukin 13 and couples to the JAK1/ 2/ 3-STAT6 pathway. The IL4response is involved in promoting Th2 differentiation. The IL4/ IL13 responses are involved in regulating IgEproduction and Chemokine and mucus production at sites of allergic inflammation. In certain cell types, IL-4RA can signal through activation of insulin Receptor substrates, IRS1/ IRS2. The functional IL4 Receptor isformed by initial binding of IL4 to IL4R. Subsequently it recruits to the complex of the common gammachain. In immune cells, IL-4RA creates a type I Receptor. In non-immune cells, it forms a type II Receptorwith of IL13RA1. IL4R can also interact with the IL13/ IL13RA1 complex to form a similar type II Receptor andinteracts with the SH2-containing phosphatases, PTPN6/ SHIP1, PTPN11/ SHIP2 and INPP5D/ SHIP.
